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Clomiphene citrate (Clomid, Serophene) is an oral tablet taken to induce ovulation in some women and to stimulate multiple follicle development in others. Clomid induces ovulation by increasing the output of certain hormones from the pituitary gland, which stimulate follicular growth in the ovary and subsequent ovulation. The usual dosage is 50-150 milligrams (one to three 50 mg tablets) taken days 3 through 7 or days 5 to 9 of the menstrual cycle. Ultrasound monitoring may be utilized and hCG (an injectable medication) may be given to assure ovulation.

Multiple birth pregnancy occurs in 9% of patients using clomid. The risk of a triplet pregnancy with clomid is less than 1%. Other side effects include: hot flashes, ovarian cyst formation (which generally resolves spontaneously), breast tenderness, and moodiness. Rarely, visual disturbances are noted which would contraindicate further use.