This test is useful as part of the evaluation for recurrent pregnancy loss and in some instances during the evaluation for infertility. It allows an assessment of how the lining of the uterus responds to the hormones produced by the ovary. It is performed in the office, takes approximately five minutes to complete, and may be associated with cramping discomfort. The procedure is scheduled late in the menstrual cycle, usually two to three days before the onset of menses or ten to twelve days after an LH surge. For most women, this will be between the 24th and 27th day of their menstrual cycle. Biopsies performed late in the menstrual cycle are used to date the development of the lining or to determine the presence of a protein called beta-integrin. In addition, an endometrial biopsy may be performed to assess for inflammation of the uterine lining. Biopsies to assess for inflammation can be performed at any time during the cycle but are often performed approximately 8 days after the onset of the menses.
Endometrial biopsy may be performed for non fertility reasons including abnormal uterine bleeding or post menopausal bleeding.
Sometimes, there is spotting after a biopsy. If you have bleeding heavier than a menstrual period or a temperature above 100.4, call the office at which you are usually seen. It is important that you call with the onset of your next menstrual cycle so we can accurately interpret the biopsy results
It is very unlikely that an endometrial biopsy will harm a pregnancy conceived during the cycle it is performed. However, we recommend that you use a mechanical form of contraception, such as condoms, during the particular menstrual cycle in which you are to undergo a biopsy. On occasion, when the biopsy is abnormal, it must be repeated during a subsequent cycle.
To schedule the endometrial biopsy, call the office at which you are usually seen, at the onset of your period the month you will have the test performed.